(54) Methods of Using Bacillus Anthracis Other Publications Protective Antigen Sequences for Vaccination

ثبت نشده
چکیده

W0 WO 01/21656 A2 W0 WO 01/82788 A2 3/2001 11/2001 Puziss et al (Journal of Bacteriology, v01. 85, 1963, p. 230-236).* Ramirez et al (Abstract of SIM Meeting, Nov. 1, 2001).* Skolnick et a1. (Trends in Biotechnology 18: 34-39, 2000).* Boslego et al (Vaccines and lmmunotherapy, 1991, Chapter 17).* Ellis (Vaccines, W.B. Saunders Company, Chapter 29, 1988, pp. 568-574).* Ahuja et al., “Rapid puri?cation of recombinant anthrax-protective antigen under nondenaturing conditions,” Biochem. Biophys. Res. Commun. 286:6-11, 2001. Baillie et al., “The expression of the protective antigen of Bacillus anthracis in Bacillus subtilis, ” J Appl. Microbiol. 84: 74 1 -746, 1998. Bartkus et al., “Transcriptional regulation of the protective antigen gene ofBacillus anthracis,”Infect. Immun. 57:2295-2300, 1989. Boslego et al. Vaccines and lmmunotherapy, 1991, Chapter 17. Bowie et al., “Decipering the Message in Protein Sequences: Toler ance to Amino Acid Substitutions,” Science 247: 1306-13 10, 1990. Chase, H.A., “Puri?cation of proteins by adsorption chromatography in expanded beds,” Trends Bi0techn0l. 12:296-303, 1994. Chauhan et al., “Constitutive expression of protective antigen gene of Bacillus anthracis in Escherichia c0li,” Biochem. Biophys. Res. Commun. 283:308-315, 2001. Chu et al., “Preparation, characterization, and immunogenicity of conjugates composed of the O-speci?c polysaccharide of Shigella dysenteriaetype 1 (Shiga’ s Bacillus) bound to tetanus toxoid,” Infect. Immun. 59:4450-4458, 1991. Coulson et al., “Bacillus anthracis protective antigen, expressed in Salmonella typhimurium SL 3261, affords protection against anthrax spore challenge,” Vaccine 12:1395-1401, 1994. Creighton, Thomas E., in his book, “Proteins: Structures and Molecu lar Properties,” 1984 (pp. 314-315). Creighton, Thomas E., in his book “Protein Structure: A Practical Approach,” 1989, (pp. 184-186). de Veth and Kolver, “Digestion of Ryegrass Pasture in Response to Change in pH in Continuous Culture,” J. Dairy Sci. 84:1449-1457, 2001. Ellis. Vaccines, W.B. Saunders Company, Chapter 29, 1988, pp. 568-574. Ezzell and Welkos, “The capsule of Bacillus anthracis, a review,” J. Appl. Microbiol. 87:250, 1999. Farchaus et al., “Puri?cation and characterization of the major sur face array protein from the avirulentBacillus anthracis Delta Sterne 1,” J. Bacteriol. 177:2481-2489, 1995. Farchaus et al., “Fermentation, puri?cation, and characterization of protective antigen from a recombinant, avirulent strain of Bacillus anthracis,”Appl. Environ. Microbiol. 64:982-991, 1998. Fellows et al., “Ef?cacy of a human anthrax vaccine in guinea pigs, rabbits, and rhesus macaques against challenge byBacillus anthracis isolates of diverse geographical origin,” Vaccine 19:3241-3247, 2001.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Construction of a Eukaryotic Plasmid Encoding Bacillus anthracis Protective Antigen, a Candidate for DNA Vaccine

Background: DNA immunization with plasmid DNA encoding bacterial, viral, parasitic and tumor antigens has been reported to trigger protective immunity. Objective: To evaluate the use of a DNA immunization strategy for protection against anthrax, a plasmid was constructed. Methods: The partialsequence of protective antigen of Bacillus anthracis, amino acids 175-764, as a potent immunogenic targe...

متن کامل

Antibody titers of PEG-PLA block copolymer nanosphere containing chimeric recombinant protein of protective antigen and lethal factor of Bacillus anthracis

Introduction: To date, many vaccines have been developed for anthrax but not yet an ideal vaccine. In this study, chimeric protein containing domain 1 lethal factor and domain 4 protective antigens of Bacillus anthracis in copolymer nanocapsules were used to solve the problems caused by existing vaccines and to increase the efficiency of the proposed vaccine. Materials and Methods: In this expe...

متن کامل

In-vitro Evaluation of the Antibacterial and Cytotoxicity Activity of the PAD4 Antigen of Bacillus anthracis as a vaccine candidate

Introduction: Infectious diseases are one of the main causes of death worldwide. This has driven scientists to invest in extraction and identification of antimicrobial agents from natural toxins and presentation of novel antibiotics and vaccines. The aim of the current study is to investigate the antibacterial and cytotoxicity effects of the protective antigen domain 4 (PAD4) from Bacillus anth...

متن کامل

In Silico Prediction of B-Cell and T-Cell Epitopes of Protective Antigen of Bacillus anthracis in Development of Vaccines Against Anthrax

Protective antigen (PA), a subunit of anthrax toxin from Bacillus anthracis, is known as a dominant component in subunit vaccines in protection against anthrax. In order to avoid the side effects of live attenuated and killed organisms, the use of linear neutralizing epitopes of PA is recommended in order to design recombinant vaccines. The present study is aimed at determining the dominant epi...

متن کامل

همسانه‌سازی و بیان ژن‌های ممزوجی دومن - a1 آنتی‌ژن حفاظتی با سیلوس آنتراسیس و زیرواحد B سم شیگلا در باکتری E. coli

Introduction: Shigella enterotoxin(STxB) is one of the major virulent factors in Shigella dysenteriae type 1 and E. coli O157:H7, which its immunogenicity, adjuvant and delivery characteristic have been proven. Anthrax is a common disease in humans and animals and identifies domain a-1 antibodies of protective antigen(PA) which is 62% of the PA antigens of Bacillus anthracis. Therefore, the pur...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2014